You can do quite a bit with a little experimentation with the 221 Fireball and get satisfying results. By that I mean loading it way down with BlueDot and 30 grain Calhoons or going for higher speeds with heavier bullets too. The 40 grain plastic tips are all good bullets, but don't overlook the Hornady 45 grain Hornet and even the Hornady 50 grain SX, depending on what you're going after. I'll post a few loads from my records. None of these are hot in my rifle, and I've only gotten high pressure indications with 4227 powder.
Both the Accurate Arms and the Nosler manuals list Fireball loads in rifle length barrels. There may be others too. If you want to use a Hodgdon Extreme Power, H4198 is a good choice. It doesn't meter quite as easily as the Reloader 7 or the AA1680, but it does offer far less variation in velocity with temperature changes.
Also, here's a ballistics table for the Fireball shooting a 50 grain SX, zeroed 1" high at 100 yards. My choice for coyotes in the north woods and the heaviest bullet I considered practical in my light rifle.
Have fun with the Fireball, it's a versatile and forgiving cartridge to load for.