Not with a 222. Max effective range for RELIABLE kills with a 222 is 200 yds. Anything more than that, the more yardage, the more iffy it gets. Having a little brother that is a Gov't trapper means we have used just about every known cartridge in the book and coyotes are one of his target animals to the tune of several thousand a year. The 222 is the picture post card of a pop gun.a good pill to take varmint at long range