It will depend on the caliber you are shooting.....
The biggest disapointment that I have had in powder selection is Varget. I have shot it in several 22/250's and several 243's and I have not been able to get tiny bug hole groups out of it with many bullet selections. In these same rifles, 4895 and 4064 did not group either which are kissing cousings to Varget.
The issue of temp sensitive seems to always come up. Until I started visiting the internet, I never knew there was a problem with powder being extremely temp sensitive while living in S.Ca and Arizona. While going on 4 p. dog hunts a year, I did realize an extreme problem of ammo being exposed to sunlight allowing the cases to get warm to the touch. The guys that live up North were it is so cold can teach the rest of us about Temp sensitive powders. They shoot in some very cold weather, then when the weather turns 75*, their cold weather loads produce way over max pressures.
Having lived in S.Ca, Arizona, and SC, I have not experienced the temp sensitive issue as much as the guys that live in Extremely cold weather have.
Having lived in more temperate climates, I am partial to Ball Powders when they will shoot with extreme accuracy.
When living in S. Ca, the temps were usually in the mid 70's or low 80's for most of the year. I then traveled to S. Dakota in the summer to shoot p. dogs when the temps got up in the 90's. My loads that I had developed with my 223 (748 powder), 6ppc (2230-S powder), 6 BR (H335 Powder), 22/250 AI
(Win 760 powder), 6/250 AI (Win 760), and 243 AI (760 Powder & AA2700). In all the cartridges above, the accuracy nodes that I shot was right at or near a Max load. In those days, I shot 15,000-25,000 rounds a year at ground squirrels, jack rabbits, chucks, coyotes, and p. dogs. Needless to say, barrels were on order almost all the time. I found out in a hurry that ball powders were easier on barrels than IMR 4064, H4895, and IMR 4350. It seems that the larger the kernel of powder the more errosive tendancies there is in barrel wear. Flame temp and duration of the Heat/Pressure is also a main issue.
I've got way off topic from the origional post. I have always thought that Guys that live in extreme Cold and then try and shoot in moderate temps in the mid 70's to low 80's are the guys that will teach the rest of us about
temp sensitive powders. The guys that live in the more moderate temps just have to use a little common sensense if/when they are shooting close to a max load. The guys that are shooting p. dogs have to learn to keep their ammo covered up.