Well, the best answer probably is: No...and Yes...and Won't matter.
Because you won't know unless and until you try. My best guess, however would be to predict standard primers will be better. RL22 isn't that hard to light, the .3-06 isn't that cavernous, and Georgia doesn't get that cold.
The usual caveats to back down when you switch components definitely applies. I'd reduce the powder charge by 2 to 5% when you switch primers.
Yes my rifle is a Rem 700 BDL action with a Shilen 26" SS #6 1 in 10 twist in a H-S Precision Pro-Series stock with a Zeiss Diavari 3-12X56 #8 reticle in Leupold mounts. It is a bean field deer killer.
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